CID1990 wrote: ↑Thu Nov 04, 2021 7:21 pm
JohnStOnge wrote:
That letter does not describe gain of function reasearch.
OK you are officially ill, JSO.
Since you are obviously impaired of in some weird fugue state, here is the first paragraph of the letter:
“A letter from Lawrence Tabak, the National Institutes of Health’s principal deputy director, to Kentucky congressman James Comer confirms that the NIH funded research at the WIV during 2018–2019 that manipulated a bat coronavirus called WIV1. Researchers at the institute grafted spike proteins from other coronaviruses onto WIV1 to see if the modified virus was capable of binding in a mouse that possessed the ACE2 receptors found in humans—the same receptor to which SARS-CoV-2 binds. The modified virus reproduced more rapidly and made infected humanized mice sicker than the unmodified virus.”
^^^^ that is PRECISELY gain of function research. Maybe you should tell us (and me with just a biology degree with an emphasis on microbiology) what YOU think GOF research is if not what is described above?
Whatever the hell is wronge with you
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Ok. I had time to go back and see where the "first paragraph" thing came from. This is apparently it. The quote is not from the first paragraph of the letter. It is a quote from a conservative opinion piece. Also, to be completely accurate, it is not the first paragraph anything. It is the second paragraph of the opinion piece.
However, I will say that opinions on exactly what "gain of function" research is vary. One example is provided by the blog piece by a Columbia University virologist at
https://www.virology.ws/2021/09/09/gain ... explained/. His take on this current situation is as follows:
GoF research has been in the press again recently as a consequence of the COVID-19 pandemic. After the SARS-CoV pandemic of 2003, wildlife sampling efforts in China revealed many SARS-like coronaviruses in bats. To assess the potential of these viruses for infecting humans, their spike protein encoding genes were substituted into the SARS-like CoV WIV1. These recombinant viruses reproduced in human airway cells – no different from WIV1 – but at least one caused more severe disease in mice. Consequently these are GoF experiments. Some have suggested that such GoF work gave rise to SARS-CoV-2 in a lab, but this notion is impossible, as none of these viruses are close enough to be a precursor of the current pandemic virus.
The production of recombinant coronaviruses to assess pandemic potential was carried out in several laboratories, all funded by the NIH. Recently Dr. Anthony Fauci told Congress that the NIH did not fund GoF coronavirus research. The press has suggested that he lied, but the truth is that his definition of GoF research is that it only involves passaged of organisms in animals. This interpretation is not correct but being wrong does not mean you are lying.
For the situation described in the NIH letter to mean the lab leak theory appears more likely there would have to be some evidence that SARS-CoV-2 is a virus created through manipulation. And that evidence does not exist. Yes, I know there was a flurry of discussion some time ago claiming that such evidence does exist. But it was debunked.